Downstream sample preparation for subsequent quality attribute analysis represents “a significant bottleneck in process development for non-antibody biologics,” wrote Kevin Brower, PhD, global head of ...

Weak protein interactions between ubiquitin and the ubiquitin-proteasome system (UPS) enzymes that mediate its covalent attachment to substrates serve to position ubiquitin for optimal catalytic ...

IT is well known that as the concentration of substrate molecules is increased, other conditions being kept constant, the rate of catalysis of a reaction by an enzyme reaches a maximum value. On the ...

The publication in ACS Catalysis, one of the world's most influential scientific journals, compares the four best performing enzymes for PET degradation under industrial conditions and confirms the ...

University of Groningen scientists observed the characteristics of a single enzyme inside a nanopore. This revealed that the enzyme can exist in four different folded states, or conformers, that play ...

Patients with LADA -- a form of autoimmune type 1 diabetes in adulthood -- can be distinguished from patients with non-autoimmune type 2 diabetes by means of the antibody reaction affinity to the ...

Protistan community grazing rates upon both bacterioplankton and autotrophic picoplankton were estimated using fluorescently-labeled prey and by measurement of extracellular hydrolysis of ...

Enzymes are biological catalysts that facilitate biochemical transformations. An international team of bioinformatics researchers has developed a new process for predicting Michaelis constants, which ...

All metabolic pathways have to be regulated and controlled to stop the build-up of an end product that isn’t needed. The cell can control a metabolic pathway by the presence or absence of a particular ...