Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...
The Gates lab studies the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and ...
Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, cancer, and metabolism. Here, we generate intestinal ...
The authors have proposed the Microbiota-derived metabolites–epigenetics (MDME) axis, a conceptual framework explaining how microbial metabolites function as a critical link between the environment ...
Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells. By ...
Molecular biologists decode the epigenetic silencing of problematic retroviral gene sequences. LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene ...
An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for ...
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Chromosomes and spindles in mature oocytes are stabilized by histone modification, study shows
The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...
The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...
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