Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for ...

Scientists have observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play an ...

Molecular biologists decode the epigenetic silencing of problematic retroviral gene sequences. LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene ...

Pharmacogenomic Strategies Provide a Rational Approach to the Treatment of Cisplatin-Resistant Patients With Advanced Cancer We used immunohistochemistry to assess histone 3 lysine 4 dimethylation ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

Salt stress remains a critical challenge for plant growth, especially in crops like pea (Pisum sativum L.). This study explores the role of histone modifications in regulating pea's response to salt ...