This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for ...

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells. By ...

Pharmacogenomic Strategies Provide a Rational Approach to the Treatment of Cisplatin-Resistant Patients With Advanced Cancer We used immunohistochemistry to assess histone 3 lysine 4 dimethylation ...

Chromatin states and their associated epigenetic information play a crucial role in maintaining the identity of cells as they divide. Histone post-translational modifications (PTMs) are important ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

While each cell contains the complete genetic blueprint of an organism, chemical marks on the DNA—so-called epigenetic modifications—control which genes are active when and where. A team led by ...

Researchers discover a 'switch' specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the modifiers ...