NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

We played a major role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We identified one of the major ...

Midline Low-Grade Gliomas of Early Childhood: Focus on Targeted Therapies As there were no previous pediatric data, ulixertinib was initially tested in a dose escalation cohort to establish the ...

Researchers from Medical University Vienna presented data from a study that aimed to identify possible synergism between the novel son of sevenless (SOS) inhibitor BAY-293 and B-Raf or/and MEK1/2 ...

Memorial Sloan Kettering Cancer Center has reported promising early clinical results for ulixertinib, a novel extracellular ...