Researchers have made many modifications to the CRISPR system since it was first developed. CRISPR is a DNA-editing tool that ...

Of the CRISPR-Cas9 tools created to date, base editors have gotten lots of attention because of their seemingly simple editing: they neatly replace one nucleic acid with another, in many cases all ...

CRISPR–Cas9 has limitations. One of the most concerning, in regards to using genome editing for therapeutic applications for humans, is off-target DNA cleavage. Although some Cas9 variants have been ...

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9—as a genetic ...

Scientists have redesigned a key component of a widely used CRISPR-based gene-editing tool, called Cas9, to be thousands of times less likely to target the wrong stretch of DNA while remaining just as ...

The CRISPR system, which involves a Cas enzyme to cut DNA, is a powerful tool for gene editing. But the genetic scissors sometimes make changes at the wrong place, creating a major safety problem that ...

The CEO of Caszyme, a biotech company in Vilnius, Lithuania, presented details of Cas12l, a novel compact Cas nuclease with a ...

The approved CRISPR-Cas9 gene therapy involves isolating hematopoietic stem cells (HSCs) from SCD patients and using CRISPR-Cas9 gene editing to reactivate fetal hemoglobin (HbF) genes that are ...

CRISPR-based gene editing just got safer with the design of a new SuperFi-Cas9 variant that more readily discriminates against mismatches and retains the accuracy and speed of naturally occurring Cas9 ...

It started with Streptococcus pyogenes. Seven years ago, the bug that causes strep throat, toxic shock syndrome, and flesh-­eating disease supplied researchers with their first gene-snipping nuclease, ...